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Literature analysis of tigecycline-induced blood coagulation dysfunction
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Ming ZHANG1, Jin WANG2, Rui WANG2, Nan BAI2, Chao AI1
Chinese Journal of New Drugs | 2021, 30(3) : 285 - 288
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Chinese Journal of New Drugs | 2021, 30(3): 285-288
Literature analysis of tigecycline-induced blood coagulation dysfunction
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Ming ZHANG1, Jin WANG2, Rui WANG2, Nan BAI2, Chao AI1
Affiliations
  • 1Beijing Tsinghua Changgeng Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
  • 2Center of Medicine Clinical Research, PLA General Hospital, Beijing 100853, China
Published: 2021-02-15
Outline
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Objective:

To analyze the general patterns and characteristics of blood coagulation dysfunction induced by tigecycline and provide reference for clinical use.

Methods:

Blood coagulation dysfunction induced by tigecycline reported in foreign and domestic academic journals were collected from China National Knowledge Infrastructure (CNKI), VIP, PubMed, Embase and SCI, and analyzed in depth.

Results:

A total of 17 patients, including 12 males and 5 females, were retrieved, and 5 of whom with abnormal liver function. Among them, 10 patients appear coagulation dysfunction in 10 d of treatment. The clinical manifestations of blood coagulation dysfunction induced by tigecycline were the significant prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) significantly decreased. After treatment, 16 patients recovered and 1 died.

Conclusion:

Clinicians and pharmacists should familiarize the pauem and characteristics of blood coagulation dysfunction induced by tigecycline, which should be used strictly in accordance with the instructions. Drug monitoring should be strengthened.

tigecycline  /  blood coagulation dysfunction  /  adverse drug reactions
张明, 王瑾, 王睿, 白楠, 艾超. 替加环素致凝血功能障碍文献分析. 中国新药杂志, 2021 , 30 (3) : 285 -288 .
Ming ZHANG, Jin WANG, Rui WANG, Nan BAI, Chao AI. Literature analysis of tigecycline-induced blood coagulation dysfunction[J]. Chinese Journal of New Drugs, 2021 , 30 (3) : 285 -288 .
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  • Online Date：2026-10-29
  • Published：2021-02-15
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History
  • Accepted：2020-03-09
Affiliations
    1Beijing Tsinghua Changgeng Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
    2Center of Medicine Clinical Research, PLA General Hospital, Beijing 100853, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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