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Research progress on design of multi-target anticancer drugs based on histone deacetylases
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Jiao-li DING1, Zhi-peng ZHANG1, Jing LIU2, Wei-xin ZHOU1, Yi JIN1, Sai-sai XIE1
Chinese Journal of New Drugs | 2021, 30(3) : 236 - 245
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Chinese Journal of New Drugs | 2021, 30(3): 236-245
Research progress on design of multi-target anticancer drugs based on histone deacetylases
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Jiao-li DING1, Zhi-peng ZHANG1, Jing LIU2, Wei-xin ZHOU1, Yi JIN1, Sai-sai XIE1
Affiliations
  • 1National Pharmaceutical Engineering Research Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • 2School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Published: 2021-02-15
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The occurrence of tumor is a complicated process involving many factors and steps. It has been well validated that multi-target anticancer drugs that can simultaneously interact with two or more targets may offer greater therapeutic benefits than single target anticancer drugs. Studies indicate that HDACs are overexpressed in different human tumor cell lines, and have been identified as key targets of tumorigenesis. Therefore, design of multi-target anticancer drugs that can simultaneously act on HDACs and other targets has become an important research direction. To date, five HDAC inhibitors have been approved for the treatment of cancers including cutaneous T-cell lymphoma, multiple myeloma and peripheral T-cell lymphoma. There are several HDAC inhibitors at various stages of clinical trials against different cancers. Based on this, this paper reviews the design and biological activity of multi-target anticancer drugs based on the structures of HDAC inhibitors in recent years, aiming to provide reference for the further development of such multi-target molecules.

HDAC inhibitors  /  multi-target  /  antitumor drugs  /  kinase  /  synergistic effect
丁娇丽, 张志鹏, 刘婧, 周维新, 金一, 谢赛赛. 基于组蛋白去乙酰化酶设计的多靶点抗肿瘤药物研究进展. 中国新药杂志, 2021 , 30 (3) : 236 -245 .
Jiao-li DING, Zhi-peng ZHANG, Jing LIU, Wei-xin ZHOU, Yi JIN, Sai-sai XIE. Research progress on design of multi-target anticancer drugs based on histone deacetylases[J]. Chinese Journal of New Drugs, 2021 , 30 (3) : 236 -245 .
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Year 2021 volume 30 Issue 3
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  • Online Date：2026-10-29
  • Published：2021-02-15
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  • Accepted：2020-04-25
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Affiliations
    1National Pharmaceutical Engineering Research Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
    2School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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