Full
Outline
To design and synthesize twin drug of tetramethylpyrazine and scutellarein for ischemic stroke.
Based upon the theory of twin drug, six targeted compounds were synthesized and their structures were confirmed by 1H-NMR and HRMS. The antioxidant and anticoagulant activities of the target compounds were studied in vitro, and the selected compound was further evaluated for cerebral ischemia/reperfusion protection using middle cerebral artery occlusion (MCAO) model.
All the tested compounds showed good effect against oxidative damage and anticoagulant activity, and the volume ratio of cerebral infarction in the high dose group of compound 4 was reduced to 23.7% compared with the MCAO group.
The twin drug strategy has certain reference value for the treatment of ischemic stroke.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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