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Outline
Oncolytic virus, as a biological agent of cancer, plays an anti-tumor role by selectively infecting and lyses tumor cells in the treatment of cancer, increasing the exposure of tumor antigens, remolding the tumor microenvironment, increasing the infiltration of immune cells in the tumor microenvironment, and activating the immune system. Because the therapeutic effect of using oncolytic virus alone is not satisfactory, and many clinical trials on the combination of oncolytic virus and other anti-cancer drugs have shown good anti-tumor effect, the application of combination of the two is expected to release the enormous potential of oncolytic virus therapy against cancer. This article reviews the anti-tumor mechanisms, application types, clinical trial status and important progress of combined therapy of oncolytic virus.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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