Full
Outline
To summarize the indexes of juvenile SD rats in control group of the 4-week repeated administration toxicity test in our laboratory, and to establish the background data of our laboratory so as to provide reference for the evaluation of non-clinical safety of pediatric drugs.
From repeated administration toxicity test of pediatrics between 2015 and 2019, the indexes of juvenile SD rats were selected and analyzed, including body weight, feed consumptions, reproductive development (preputial separation and vaginal patency), skeletal development (crown-rump length, tibia length and bone density), hematology, blood biochemistry, immunization and viscera index.
The mean value, standard deviation, maximum and minimum values, 95% confidence interval as well as coefficient of variation of all indicators from juvenile SD rats in different genders were obtained through statistical analysis.
The reference ranges of normal values of juvenile SD rats for different genders and ages were established.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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