Full
Outline
A prediction model for the granule growth profiles in fluidized bed of traditional Chinese medicine was developed to improve the research and development of traditional Chinese medicine preparation technology from laboratory trial and error to scientific, digital and intelligent mode.
The basic working conditions of the fluidized-bed top spray granulator were constructed by SolidWorks Premium software, and the grid was then divided by ANSYS ICEM CFD software. Computational fluid dynamics (CFD) was used to establish the mathematical model of granules agglomeration. The agglomeration mechanism rules were customized and the user-defined functions were cooperated into the model. The established CFD model was used to simulate the granulation process of Lysimachia christinae Hance extract and Sedum sarmentosum Bunge extract in a fluidized bed respectively. Furthermore, the fluidized bed granulation experiments were carried out to verify the accuracy of the model.
The simulation results showed that the particle size of the granules increased with the increasing simulation time, and the particle size distribution gradually widened. The velocity of the particles and the pressure of the mixed phases in the bed changed due to the particle growth. The experimental results of granules size growth rate and spatial distribution were in good agreement with those of numerical simulation.
The simulation of granule growth trend can be used to predict or judge the appropriateness of the formulation process and is helpful to effectively control the key quality attributes of the final granules.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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