Full
Outline
To investigate the influence factors of blood concentration of tacrolimus, and to provide reference for clinical use of tacrolimus (FK506).
66 patients with nephrotic syndrome, who received hospitalized treatment in nephrology department of our hospital were enrolled in this study. The blood concentration of FK506, general data and laboratory testing values and so on, were recorded and analyzed using multiple linear regression method by SPSS 17.0 software.
Among the 66 patients, 40.91% patients' FK506 concentration fell in the effective range, 54.55% below the effective range, and 4.55% above the effective range. Correlations were found in unit dose of blood concentration for tacrolimus with total cholesterol (CHO) combination with drugs that increase the FK506 blood concentration, and serum creatinine (P<0.01).
The FK506 blood concentration in patients with nephrotic syndrome patients is greatly varied between individuals, and CHO, drugs that increase FK506 concentration and CK are main factors affecting FK506 blood concentration in nephrotic syndrome patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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