Full
Outline
To evaluate the effectiveness, safety and economy of Binkgo biloba extract injection in ischemic stroke patients using rapid health technology assessment and to help efficiently and quickly provide evidence-based basis for clinical drug selection and decision makers.
Databases in Chinese and English, and HTA organization websites were searched. Studies were selected according to the inclusion and exclusion criteria, and the data were extracted and the quality of included literature was evaluated and analyzed.
At last, 7 systematic reviews and 4 pharmacoeconomic studies were included in this study. In patients with ischemic stroke, Ginkgo biloba extract injection improved clinical efficacy, neurological deficit scores and activity of daily living, ameliorated plasma viscosity and reduced fibrinogen, as well as improved the deterioration rate of the disease. There was no statistically significant difference in mortality compared with the control group. Few adverse reactions and no serious adverse reactions were observed. The quality of the included economics research literature was relatively low. Drug efficacy in experimental group and control group was equal. The cost-effectiveness analysis method was adopted in the economic evaluation, in which only the drug cost out of direct cost was included. The year of research is relatively early, which cannot match the current drug price, and results of the researches are difficult to be used as reference.
Ginkgo biloba extract injection is an efficacious and safe choice for ischemic stroke treatment. The evaluation of its economics still requires further high-quality pharmacoeconomic analysis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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