Full
Outline
To synthesize a series of Bola type nonionic surfactants using 1, 12-dodecanediol and undecenoic acid as raw materials, characterize the products and evaluate the safety.
Dodecyl Di-10-undecenoate was prepared by esterification, epoxidation was conducted on the product followed by ring opening to prepare disubstituted polyoxyethylene undecanoate dodecyl with different degrees of polymerization glycol ester, and the products were compared with the nonionic surfactant Tween 80 in terms of surface activity, solubilization, hemolysis, etc.
The safe and effective index of PUDD-800 was 10 times that of Tween 80.
PUDD-800 can replace the commercially available surfactants and has the potential for further application in the development of injection formulations.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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