Full
Outline
To analyze the characteristics of serious adverse reactions (ADRs) caused by rituximab in order to provide reference for rational clinical use of rituximab.
A total of 35 serious ADR reports associated with rituximab were collected in Beijing from 2003 to 2019 and further analyzed.
Among the 35 cases of serious ADRs, there were 18 males and 17 females involved. The average age of the patients was 60±17. Systemic symptoms and respiratory system damage ranked the first, and the occurrence time varied from 30 min to 7 mo after treatment. As a result of serious ADRs, 1 case died, 4 cases aggravated, 12 cases prolonged the course of disease, and 18 cases had no obvious effect on the original disease.
The monitoring over middle-aged and elderly patients and serious ADR patients should be strengthened. If serious ADRs occur, the drug should be stopped in time, and the treatment and rescue should be actively taken so as to ensure the safety of the drug application.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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