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Correlation analysis between methotrexate serum concentration and renal function in children with medulloblastoma
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Zheng-yuan SHI1, 2, 3, Xi-qiao XU1, 2, 3, Chun-jing YANG1, 2, 3, Lu YANG1, 2, 3
Chinese Journal of New Drugs | 2021, 30(8) : 701 - 704
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Chinese Journal of New Drugs | 2021, 30(8): 701-704
Correlation analysis between methotrexate serum concentration and renal function in children with medulloblastoma
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Zheng-yuan SHI1, 2, 3, Xi-qiao XU1, 2, 3, Chun-jing YANG1, 2, 3, Lu YANG1, 2, 3
Affiliations
  • 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • 2Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • 3Joint Laboratory for International Cooperation of Bio-characteristic Profiling for Evaluation of Clinical Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Published: 2021-04-30
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Objective:

To analyze the correlation between blood drug concentration and kidney injury in children with medulloblastoma treated with high-dose methotrexate (HD-MTX) chemotherapy.

Methods:

A total of 139 children with medulloblastoma treated with high-dose methotrexate chemotherapy were selected and their 782 blood drug concentrations, basic data, and laboratory examination results before and after treatment were retrospectively collected to analyze the correlation between changes in kidney function indicators and blood drug concentration.

Results:

Serum MTX concentrations at 24 h post medication were positively correlated with uric acid level, negatively correlated with creatinine clearance, but not with serum creatinine and blood urea nitrogen levels. Serum concentrations of MTX at 42 h post medication were positively correlated with serum creatinine and blood urea nitrogen levels, negatively correlated with creatinine clearance and blood urea nitrogen level.

Conclusion:

Monitoring of MTX serum concentration can predict the kidney damage caused by MTX chemotherapy.

methotrexate  /  medulloblastoma  /  serum concentration  /  kidney damage
时正媛, 续茜桥, 杨春静, 杨璐. 髓母细胞瘤患儿甲氨蝶呤的血药浓度与肾功能的相关性研究. 中国新药杂志, 2021 , 30 (8) : 701 -704 .
Zheng-yuan SHI, Xi-qiao XU, Chun-jing YANG, Lu YANG. Correlation analysis between methotrexate serum concentration and renal function in children with medulloblastoma[J]. Chinese Journal of New Drugs, 2021 , 30 (8) : 701 -704 .
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Year 2021 volume 30 Issue 8
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  • Online Date：2026-10-28
  • Published：2021-04-30
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History
  • Accepted：2020-12-29
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Affiliations
    1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    2Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    3Joint Laboratory for International Cooperation of Bio-characteristic Profiling for Evaluation of Clinical Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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