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Selection of teratogenic drugs for reproductive and developmental toxicity test in non-human primates
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Yan-jun CUI1, Yi-chao TIAN1, Li ZHOU2, 3, Zu-yue SUN2, 3
Chinese Journal of New Drugs | 2021, 30(14) : 1266 - 1273
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Chinese Journal of New Drugs | 2021, 30(14): 1266-1273
Selection of teratogenic drugs for reproductive and developmental toxicity test in non-human primates
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Yan-jun CUI1, Yi-chao TIAN1, Li ZHOU2, 3, Zu-yue SUN2, 3
Affiliations
  • 1Hubei Topgene Biotechnology Co., Ltd., Wuhan Branch, Wuhan 430075, China
  • 2Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
  • 3Reproductive and Developmental Research Institute of Fudan University, Shanghai 200032, China
Published: 2021-07-30
Outline
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The reproductive and developmental toxicity evaluation on non-human primates is required urgently as the booming of biotechnological drugs. The selection of positive drugs is vital for establishment of the test system when there is less experience in domestic safety evaluation centers. There are different kinds of teratogens reported to both human and animals such as rodents, rabbits, but less on non-human primates. In this paper the potential teratogens to non-human primates were reviewed according to the literature.

non-human primate  /  reproductive and developmental toxicity  /  model  /  teratogenic drugs
崔艳君, 田义超, 周莉, 孙祖越. 非人灵长类动物胚胎-胎仔毒性实验阳性药物的选择. 中国新药杂志, 2021 , 30 (14) : 1266 -1273 .
Yan-jun CUI, Yi-chao TIAN, Li ZHOU, Zu-yue SUN. Selection of teratogenic drugs for reproductive and developmental toxicity test in non-human primates[J]. Chinese Journal of New Drugs, 2021 , 30 (14) : 1266 -1273 .
Year 2021 volume 30 Issue 14
47
8
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  • Online Date:2026-10-28
  • Published:2021-07-30
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  • Accepted:2021-05-18
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Affiliations
    1Hubei Topgene Biotechnology Co., Ltd., Wuhan Branch, Wuhan 430075, China
    2Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
    3Reproductive and Developmental Research Institute of Fudan University, Shanghai 200032, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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