Full
Outline
To investigate the changes of the plasma metabolic spectrum of C57BL/6 young mice treated with different doses of nano-TiO2, explore the possible mechanism of its toxic side effects, and identify its toxicity-related biological targets.
Mice were randomly assigned to receive nano-TiO2 at doses of 0 (control group), 10, 30, 100, or 300 mg·kg-1. The plasma data were analyzed using UPLC-MS technology combined with principal component and partial least squares analyses. The results revealed differences between the control group and each nano-TiO2 group, with the effect becoming more pronounced with increasing doses. Topological analysis of the different metabolites was conducted using the Pathway Analysis database.
In total, 35 different metabolites were screened from plasma, and Nano-TiO2 treatment was revealed to affect linoleic acid metabolism, biosynthesis of valine, leucine and isoleucine, sphingolipid metabolism, arachidonic acid metabolism, glycerophospholipid metabolism, nicotinate and nicotinamide metabolism, histidine metabolism, and other pathways.
The results indicated that the toxicity mechanism of Nano-TiO2 after 28 days of exposure may be related to abnormal amino acid and lipid metabolism.
54
13
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
