The international status of traditional Chinese medicines is constantly improving, and the research of modern pharmacology on their active ingredients and pharmacological activities promotes the development and clinical application. However, with the increasing application of traditional Chinese medicines, more attention should be paid to their toxicity and clinical side effects. Most Chinese medicinal materials have cardiovascular toxicity and poor clinical prognosis, which is also the main factor of death caused by excessive use. Therefore, it is vital to explore the cardiotoxicity of traditional Chinese medicines applied in clinic, seek efficient preventive measures and look for treatment methods. In “the measures for the management of toxicity for medical use”, Datura metel L, Aconitum carmichaeli Debx, Realgar, Hyoscyamus niger L, Hydrargyri oxydum Rubrum, Aconitum vilmorinianum Kom, Strychnos nux-vomica L, Toad venom, Euphorbia Lathyris L, Aconitum brachypodun Diels, Radix Aconiti, Realgar, Calomelas, Hydrargyrum and Mylabris phalerata Pallas are defined as toxic herbs. In this paper, the existing literature is reviewed to summarize the toxic and side effects of toxic traditional Chinese medicines on cardiovascular system, as well as the detoxification methods, so as to provide references for the clinically effective treatment of toxic traditional Chinese medicines.