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Hepatocyte growth factor receptor inhibitor capmatinib for the treatment of non-small cell lung cancer
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Ying TONG1, Lu HUANG2, 3, 4, Chuan-shuang XIONG1, Yi HONG1, Yong XU1
Chinese Journal of New Drugs | 2021, 30(14) : 1255 - 1259
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Chinese Journal of New Drugs | 2021, 30(14): 1255-1259
Hepatocyte growth factor receptor inhibitor capmatinib for the treatment of non-small cell lung cancer
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Ying TONG1, Lu HUANG2, 3, 4, Chuan-shuang XIONG1, Yi HONG1, Yong XU1
Affiliations
  • 1School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
  • 2School of Pharmaceutical Sciences, Wuhan University, Wuhan 430072, China
  • 3School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China
  • 4Guangzhou Wellhealth Bio-pharma Co., Ltd., Guangzhou 510200, China
Published: 2021-07-30
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Capmatinib is a hepatocyte growth factor receptor (MET) inhibitor, which was approved by the US FDA on May 6, 2020 for the treatment of adult patients with non-resectable locally advanced or metastatic non-small cell lung cancer with MET14 exon jumping mutation. This approval means another significant innovation in the treatment of NSCLC patients with MET mutation after the listing of Tepmetko®. In this paper, the mechanism of action, pharmacokinetics, pharmacodynamics, clinical research, safety and intellectual property right of the drug were reviewed.

capmatinib  /  hepatocyte growth factor receptor inhibitor  /  non-small cell lung cancer  /  clinical research  /  safety  /  intellectual property right
童颖, 黄璐, 熊传爽, 洪怡, 许勇. 用于非小细胞肺癌治疗的肝细胞生长因子受体抑制剂capmatinib. 中国新药杂志, 2021 , 30 (14) : 1255 -1259 .
Ying TONG, Lu HUANG, Chuan-shuang XIONG, Yi HONG, Yong XU. Hepatocyte growth factor receptor inhibitor capmatinib for the treatment of non-small cell lung cancer[J]. Chinese Journal of New Drugs, 2021 , 30 (14) : 1255 -1259 .
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Year 2021 volume 30 Issue 14
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  • Online Date：2026-10-28
  • Published：2021-07-30
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  • Accepted：2020-10-20
Affiliations
    1School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
    2School of Pharmaceutical Sciences, Wuhan University, Wuhan 430072, China
    3School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China
    4Guangzhou Wellhealth Bio-pharma Co., Ltd., Guangzhou 510200, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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