Full
Outline
To investigate the effect of glycyrrhizic acid (GL)-loaded F127/TPGS-MMs in mice model of atopic dermatitis (AD).
GL-F127/TPGS-MMs was prepared by thin film dispersion method and characterized by particle size, entrapment efficiency, drug loading and morphology. A AD model was induced by 2, 4-dinitrochlorobenzene (DNCB) in female BALB/c mice. And then the mice were divided into 9 groups: normal control group, model group, dexamethasone positive group (30 mg·kg-1), low (25 mg·kg-1), medium (50 mg·kg-1) and high (100 mg·kg-1) doses of glycyrrhizic acid solution groups and GL-F127/TPGS-MMs group. After oral administration for 14 days, the mice's serum level of IgE, ear swelling degree, thymus index, spleen index, skin thickness, and pathological changes of skin lesions were detected to evaluate the therapeutic effects of GL-F127/TPGS-MMs on AD in mice.
Compared with the model group, the skin lesion scores of the GL-F127/TPGS-MMs groups significantly decreased on the 28th day of model establishment (P<0.05). After intragastric administration for 14 days, the levels of IgE, ear swelling degree, thymus index, spleen index and skin lesion thickness of mice in GL-F127/TPGS-MMs groups significantly decreased (P<0.05 or 0.01) compared with the model group. The thickness of the epidermis and dermis significantly increased in the model control group and significantly reduced in GL-F127/TPGS-MMs group according to the pathological changes of the skin lesions. Compared with the GL solution groups, the AD pathological changes of the mice in GL-F127/TPGS-MMs high-dose group were significantly improved, and the epidermal hyperplasia, dermal inflammatory infiltration, and intracellular and intercellular edema were significantly reduced.
GL-F127/TPGS-MMs has a significant therapeutic effect on AD in mice.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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