Full
Outline
To evaluate the efficacy, safety and pharmacoeconomics of dutastreride in the treatment of benign prostatic hyperplasia to meet the demand of decision-making.
CNKI, Wanfang, Pubmed, the Cochrane Library and CRD databases were systematically searched. Studies were selected according to the inclusion and exclusion criteria, and the data were extracted. The quality of included literature was separately evaluated and analyzed by 2 reviewers.
Finally, 10 systematic reviews and 11 pharmacoeconomic studies were included. The results suggested that dutasteride alone or combined with tamsulosin can effectively improve International Prostate Symptom Score, increase maximum urine flow, delay the growth of prostate volume, and reduce acute urinary retention and prostate-related surgery. The incidence of sexual adverse events is higher, including decreased libido, erectile dysfunction, abnormal ejaculation and so on. Compared with finasteride, there was no significant difference in efficacy and safety. Foreign studies showed that the combination therapy of dutasteride and tamsulosin had economic advantages compared with tamsulosin alone, while domestic economic research results were inconsistent.
As a drug treating benign prostatic hyperplasia, dutasteride has good efficacy and safety; however, it has no advantages over finasteride, and the reliable conclusion needs the support of more head-to-head direct tests of dutasteride and finasteride.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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