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Outline
Depression is a common neurological disorder, the pathogenesis of which is still unclear. Glu-tamate is one of the major excitatory neurotransmitters in the central nervous system. Increasing evidences show that glutamatergic system plays a key role in the occurrence and development of depression. In antidepressant therapy, NMDA receptor antagonists can produce rapid and lasting antidepressant effects, which is one of the important targets for the development of new anti-depressants. This article will focus on the glutamatergic system, and summarize the effects of antidepressant and research status of different non-selective NMDA receptor antagonists and selective NMDA receptor antagonists [subunit (NR2B)-specific NMDA receptor antagonists], providing new basis for the development of novel antidepressants and the treatment of depression.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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