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Outline
Lactotol was first registered by Novartis in Switzerland in 1985. Its trade name is Importal. It is used for the treatment of hyperammonemia caused by hepatic encephalopathy. On February 12, 2020, it was approved by the US FDA for the treatment of chronic idiopathic constipation in adults. Its trade name is Pizensy. Latitol can increase the defecation frequency of patients, and the treatment efficacy for chronic idiopathic constipation in adults is not inferior to that of rubiprostone. The most common adverse reactions are upper respiratory tract infection, abdominal distension and diarrhea. The mechanism of action, pharmacokinetics, effectiveness, and safety of lactitol were reviewed in this article.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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