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First-line drug therapies for treating acute gout flares: a systematic review and pharmacoeconomic analysis
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Chao-feng ZHANG1, Xiao-li LIU2, Xue-juan LI2, Qi LIN3, Hai-bin LIN4
Chinese Journal of New Drugs | 2021, 30(16) : 1530 - 1536
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Chinese Journal of New Drugs | 2021, 30(16): 1530-1536
First-line drug therapies for treating acute gout flares: a systematic review and pharmacoeconomic analysis
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Chao-feng ZHANG1, Xiao-li LIU2, Xue-juan LI2, Qi LIN3, Hai-bin LIN4
Affiliations
  • 1Putian University Department of Hematology and Rheumatology, the Affiliated Hospital, Putian 351100, China
  • 2Putian University School of Pharmacy and Medical Technology, Putian 351100, China
  • 3Putian University Department of Pharmacy, the Affiliated Hospital, Putian 351100, China
  • 4Putian University Department of Orthopedics, the Affiliated Hospital, Putian 351100, China
Published: 2021-08-30
Outline
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Objective:

To evaluate the efficacy, safety and economy of nonsteroidal anti-inflammatory drugs (NSAIDs), selective cycleooxygenase-2 receptor inhibitors (COXIBs), glucocorticoids (GC), and colchicine (COLC) in the treatment of acute gout flare by Meta-analysis.

Methods:

Literature about randomized controlled trails (RCT) using NSAIDs, COXIBs, GC and COLC in the treatment of acute gout flare was searched through Medline, Embase, CENTRAL, CBM and CNKI up to Mar. 2021 and then screened according to the inclusion and exclusion criteria. The data was extracted and assessed for the methodological quality of included studies. Then, Meta-analysis was performed by using R programming and pharmacoeconomics analysis was conducted.

Results:

A total of 19 RCTs involving 2 598 patients were included. The results of network Meta-analysis showed that NSAIDs, COXIBs and GC could alleviate patients' pain effectively and improve study joint swelling (P<0.05). COLC had the highest incidence of adverse events among the four kinds of therapeutic drugs. Cost-minimization analysis showed that GC was the most economical treatment.

Conclusion:

NSAIDs, COXIBs, GC and COLC can effectively treat acute gout flare, and GC treatment is the most economical.

acute gout flares  /  nonsteroidal anti-inflammatory drugs  /  selective cycleooxygenase-2 receptor inhibitors  /  corticosteroids  /  colchicine  /  pharmacoeconomics
张超凤, 刘晓莉, 李雪娟, 林琦, 林海滨. 痛风急性发作一线药物治疗方案的系统评价及药物经济学分析. 中国新药杂志, 2021 , 30 (16) : 1530 -1536 .
Chao-feng ZHANG, Xiao-li LIU, Xue-juan LI, Qi LIN, Hai-bin LIN. First-line drug therapies for treating acute gout flares: a systematic review and pharmacoeconomic analysis[J]. Chinese Journal of New Drugs, 2021 , 30 (16) : 1530 -1536 .
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Year 2021 volume 30 Issue 16
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Article Info
  • Online Date：2026-10-28
  • Published：2021-08-30
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History
  • Accepted：2021-05-07
Funding
Affiliations
    1Putian University Department of Hematology and Rheumatology, the Affiliated Hospital, Putian 351100, China
    2Putian University School of Pharmacy and Medical Technology, Putian 351100, China
    3Putian University Department of Pharmacy, the Affiliated Hospital, Putian 351100, China
    4Putian University Department of Orthopedics, the Affiliated Hospital, Putian 351100, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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