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Outline
To observe the effects of Compound Cortex Phellodendri Fluid on inflammatory factors, nuclear factor-kappa B (NF-κB) and cyclooxygenase-2 (cyclooxygenase-2, COX-2) protein expression in rats with ulcerative colitis (ulcerative colitis, UC), and explore the protective mechanism.
The experimental animals were randomly divided into blank control group, model group and Compound Cortex Phellodendri Fluid group. The UC rat model was established by immune complex method. After 14 days of treatment, the contents of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined by ELISA method. Nuclear factor-κB and cyclooxygenase-2 were determined by Western Blot method.
Compared with the blank group, the contents of IL-6 and TNF-α and the expression of NF-κB and COX-2 protein in the model group increased, while the contents of IL-6 and TNF-α, and the expression of NF-κB and COX-2 protein in the Compound Cortex Phellodendri Fluid group decreased.
The protective effect of Compound Cortex Phellodendri Fluid on UC rats may be produced through anti-inflammatory effect.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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