Full
Outline
Rheumatism immunity disease is one of the chronic diseases which affect health seriously. A series of biological agents targeting cytokines have greatly improved the prognosis and quality of life of patients, but still can not meet the needs of disease treatment, thus searching new drugs has become an important task in the treatment of rheumatoid immune diseases. JAK-STAT is an important signaling pathway, which is involved in the development of many autoimmune diseases. JAK inhibitors can block the production of a variety of inflammatory cytokines and have anti-inflammatory and immunomodulatory effects. JAK inhibitors are gaining increasing attention in the field of rheumatologic disorders. In this review, the application status and prospect of these drugs in autoimmune diseases are summarized for the first time.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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