Full
Outline
Solid dispersion (SD) is one of the most valuable methods to improve the solubility, dissolution rate and oral bioavailability of poorly soluble drugs. SD disperses poorly soluble drugs into carrier materials, and improves the solubility and dissolution of drugs by changing their dispersion state, increasing specific surface area, increasing wettability, and so on, so as to improve the bioavailability. Dissolution is one of the most important pharmacological properties of SD and is the basis for determining whether it can successfully improve the bioavailability for the poorly soluble drugs. In SD, the carrier material is the largest component in the formulation, and the nature of it is an important factor that affects the dissolution process and dissolution behavior. Based on these, this article reviews the effects of carrier materials on the dissolution behavior and saturation solubility of SD, and provides references of selecting a suitable carrier material for SD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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