Full
Outline
To observe the clinical efficacy and safety of butylphthalide injection in the treatment of patients with anterior choroidal artery infarction, as well as the changes of serum high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α).
Sixty-seven patients with anterior choroidal artery diagnosed in our hospital were selected and randomly divided into butylphthalide group (34 cases) and control group (33 cases). Both groups received antiplatelet aggregation and lipid-lowering therapy, and the butylphthalide group was treated with butylphthalide injection 25 mg (bid) in addition for 14 d. The patients were followed up for 3 month.
The incidence of progressive stroke in the butylphthalide group was significantly lower than that in the control group. The National Institutes of Health Stroke Scale (NIHSS) scores of patients in the butylphthalide group 14 d after treatment were significantly lower than those in the control group. Three months later, the proportion of patients with good prognosis (mRS score≤1, Barthel index score≥90) was significantly higher than that of the control group (P<0.05). The levels of hs-CRP and TNF-α in the two groups were decreased on the 14th day, and the decrease in the butylphthalide group was more significant than that in the control group (P<0.05).
Butylphthalide injection can not only reduce the incidence of progression in patients with anterior choroidal artery infarction, but also has better long-term clinical efficacy and can bring higher quality of life to the patients. The mechanism may be related to reducing the levels of hs-CRP and TNF-α and inhibiting inflammatory reaction.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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