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Outline
To explore the roles of standardized judgement, risk assessment and emergency treatment of hypersensitivity reactions (HSRs) of anti-tumor monoclonal antibody drugs.
The literature of anti-tumor drugs, monoclonal antibodies and HSRs was retrieved from China National Knowledge Infrastructure (CNKI) and PubMed from January 1, 2010 to October 1, 2021. The definition and classification of HSRs, risk factors and novel treatment were analyzed.
A total of 63 pieces of literature were included, of which 22.1% did not clearly define the type of HSRs. The frequencies of infusion reactions of Fully Human Mab and Humanized Mab were reported to be 56.7% and 43.1%, respectively. The frequency of reported HSRs in intravenous drugs was significantly higher than that in subcutaneous ones (88.5% vs 11.5%); the frequency of HSRs reported in patients was significantly higher than that in healthy subjects (58.7% vs 20.2%).
The terminology of HSRs needs to be standardized. The degree of risk could be related to the drug characteristic, the method of administration, and the population of medication. The treatment of acute HSRs needs to be standardized, systematized and individualized. Rapid drug desensitization (RDD) might be novel and beneficial treatment for tumor patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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