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Research and development advancement of anti-cancer inhibitors targeting KRAS signaling pathway
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Jia-ruo XU, Yu-ying ZHU, Guang-tao YAO, Jian-ge ZHANG
Chinese Journal of New Drugs | 2021, 30(23) : 2189 - 2193
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Chinese Journal of New Drugs | 2021, 30(23): 2189-2193
Research and development advancement of anti-cancer inhibitors targeting KRAS signaling pathway
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Jia-ruo XU, Yu-ying ZHU, Guang-tao YAO, Jian-ge ZHANG
Affiliations
  • Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2021-12-15
Outline
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Based on the universality and significance of KRAS mutation in human cancer in recent years, the development of drugs targeting KRAS and KRAS-related drug screening have become the current research hotspots. The research strategies and development status of small-molecule KRAS inhibitors as well as existing effective small-molecule KRAS inhibitors were reviewed in this paper, in favor of providing new ideas and strategies for new drug development of KRAS mutated tumors.

KRAS gene  /  mutation  /  anti-tumor  /  treatment strategy  /  inhibitor
徐嘉若, 朱玉莹, 姚广涛, 张建革. 靶向KRAS信号通路的抗肿瘤抑制剂研发现状. 中国新药杂志, 2021 , 30 (23) : 2189 -2193 .
Jia-ruo XU, Yu-ying ZHU, Guang-tao YAO, Jian-ge ZHANG. Research and development advancement of anti-cancer inhibitors targeting KRAS signaling pathway[J]. Chinese Journal of New Drugs, 2021 , 30 (23) : 2189 -2193 .
Year 2021 volume 30 Issue 23
43
7
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  • Online Date:2026-10-28
  • Published:2021-12-15
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  • Accepted:2021-05-14
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    Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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