Full
Outline
To observe the influence of myrtol standardized (MS) on the Nrf2/HO-1 pathway in chronic obstructive pulmonary disease (COPD) rats, and explore the possible mechanism of MS in treating COPD.
Wistar rats were randomly divided into four groups: one was control group (CON), while the other three groups were exposed to cigarettes (CS) for 90 d to establish a COPD model firstly, then one group was given CS exposure (CSM) continuously, one group was quitted CS exposure (QSM), the other one group was quitted CS exposure and then given MS treatment (MSM), all the operations lasted for 30 d. After the modeling, the respiratory function, serum inflammatory factors (IL6, TNF-α), and lung tissue anti-oxidative stress indicators (T-SOD, MDA) were detected, HE staining of lung tissue was observed, and the expressions of Nrf2 and HO-1 in lung tissue by WB were analyzed.
The respiratory function of the CSM group decreased significantly (P<0.05), and the respiratory function of the QSM and MSM groups improved (P<0.05); the IL6 and TNF-α levels of the MSM group were significantly lower than those of the CSM group (P<0.05), and the T-SOD level increased (P<0.05), MDA decreased (P<0.05); HE staining showed emphysema-like forms in the lung tissues of the CSM group, MSM group could improve the abnormal structure of lung tissue. Meanwhile, the expressions of Nrf2 and HO-1 protein in the MSM group were relatively increased than the CSM and QSM groups (P<0.05), which was close to the CON group (P>0.05).
MS could significantly improve the respiratory function of COPD rats, reduce inflammation and infiltration, and weaken oxidative stress. Its internal mechanism is closely related to the activation of the Nrf2/HO-1 pathway.
51
11
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
