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Development and challenges of mRNA-based therapeutics
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Ling-li YU1, Xiang-yu LI1, Gui-liang CHEN1, Wu HE2
Chinese Journal of New Drugs | 2021, 30(22) : 2029 - 2033
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Chinese Journal of New Drugs | 2021, 30(22): 2029-2033
Development and challenges of mRNA-based therapeutics
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Ling-li YU1, Xiang-yu LI1, Gui-liang CHEN1, Wu HE2
Affiliations
  • 1Shanghai Center for Drug Evaluation and Inspection, Shanghai 201203, China
  • 2Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China
Published: 2021-11-30
Outline
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mRNA-based drug has already become a focus as a potential new type of drug in recent years. With the rapidly evolving technologies, mRNA has been widely applied in various areas of clinical research, such as immune disease, oncological disease, infectious disease, and congenital metabolic disorder. Since the outbreak of COVID-19, there has been a great leap in mRNA vaccine development, forecasting that much more mRNA medicines will enter the market in the near future. In order to meet industrial requirements, this article provides an overview of the product profiles of mRNA-based drugs and their industrial landscape, and further discusses the key considerations in the manufacturing of such medicines.

mRNA therapeutics  /  IVT mRNA  /  mRNA manufacturing
于玲莉, 李香玉, 陈桂良, 何伍. mRNA药物的研发及挑战. 中国新药杂志, 2021 , 30 (22) : 2029 -2033 .
Ling-li YU, Xiang-yu LI, Gui-liang CHEN, Wu HE. Development and challenges of mRNA-based therapeutics[J]. Chinese Journal of New Drugs, 2021 , 30 (22) : 2029 -2033 .
Year 2021 volume 30 Issue 22
44
9
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  • Online Date:2026-10-28
  • Published:2021-11-30
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  • Accepted:2021-06-24
Affiliations
    1Shanghai Center for Drug Evaluation and Inspection, Shanghai 201203, China
    2Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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