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Outline
Tarlatamab is an innovative targeted immunotherapy agent that simultaneously binds to delta-like ligand 3 (DLL3) expressed on tumor cell surfaces and CD3 expressed on cytotoxic T-cell surfaces. As a DLL3/CD3-targeted bispecific T-cell engager (BiTE), it activates T cells to release inflammatory cytokines, thereby killing tumor cells expressing DLL3 protein. In May 2024, tarlatamab received accelerated approval from the U.S. FDA for the treatment of adult patients with extensive-stage small cell lung cancer that has progressed during or after platinum-based chemotherapy. This article provides an overview of tarlatamab's basic information, mechanism of action, pharmacokinetics, clinical trials, and safety, to provide a reference for clinical application.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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