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Outline
Ovarian cancer (OVCA) is a gynecological malignancy that poses a serious threat to women's health and life. Despite significant advances in modern medicine and surgery in recent years, the five-year survival rates for patients with stages Ⅲ and Ⅳ OVCA are only 27% and 13%, respectively. Tumor-infiltrating lymphocytes (TILs) are a type of immune cell that infiltrate the tumor parenchyma or stroma. Compared to non-tumor-infiltrating lymphocytes, TILs exhibit a stronger ability for antitumor immune responses. TIL therapy is an innovative cell-based treatment in which the therapeutic preparation is derived from the selection and expansion of autologous TILs obtained from the patient's own tumor tissue, offering potent antitumor activity and low off-target toxicity. Studies have shown that extensive TIL infiltration is associated with improved prognosis in OVCA patients after clinical treatment, and early-phase clinical trials have also demonstrated the feasibility of TIL therapy for OVCA. This review focuses on key TILs within the ovarian tumor microenvironment, the clinical translation of TIL therapy, and the potential challenges and optimization strategies for its clinical application, aiming to provide a scientific reference for TIL-based treatment of OVCA.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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