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This paper reviews the research progress of sodium zirconium cyclosilicate, a novel potassium binder. Sodium zirconium cyclosilicate is a non-absorbed, insoluble, non-polymer inorganic crystalline powder with a uniform microporous structure, and functions as a highly selective inorganic cation exchanger. When taken orally, it captures potassium ions in the human intestinal tract, which are then excreted in the feces. By reducing potassium ion absorption, it lowers the potassium ion level in the blood, thereby treating hyperkalemia. Sodium zirconium cyclosilicate has a high affinity for potassium ions that is unaffected by other cations. Compared with existing treatments for hyperkalemia, it offers improved selectivity and speed in capturing excess potassium ions, providing a safe and effective option for the long-term management of hyperkalemia. This article describes in detail the chemical structure, mechanism of action, pharmacokinetic characteristics, clinical research progress and pharmaceutical research progress of sodium zirconium cyclosilicate. Studies have shown that sodium zirconium cyclosilicate demonstrates favorable efficacy and safety in the treatment of hyperkalemia, offering a new option for clinical practice.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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