Full
Outline
To investigate the pharmacological basis and potential mechanism of Chuanbei Qingfei Syrup in the treatment of viral pneumonia based on UPLC-Q-Exactive Orbitrap-HRMS and network pharmacology.
UPLC-Q-Exactive Orbitrap-HRMS was employed for qualitative characterization of the chemical constituents of Chuanbei Qingfei Syrup. Active compounds and their corresponding targets were identified using the TCMSP and BATMAN-TCM databases, while viral-pneumonia-related targets were retrieved from GeneCards and OMIM. The intersection of the two target sets was obtained with Venny 2.1.0. Protein-protein interaction networks were constructed via the STRING 11.0 database and visualized in Cytoscape. Finally, GO functional annotation and KEGG pathway enrichment analysis of the common targets were performed using the DAVID database.
A total of 256 constituents were identified in Chuanbei Qingfei Syrup. Network pharmacology revealed 113 targets overlapping with viral pneumonia, including 35 hub genes such as TNF, IL-6, IL-1β, and STAT3. GO enrichment indicated that the syrup modulates viral pneumonia mainly through biological processes related to gene expression, apoptosis, and inflammatory response. KEGG analysis further showed that the principal signaling pathways involved include AGE-RAGE, TNF, and IL-17 signaling.
Chuanbei Qingfei Syrup exerts therapeutic effects against viral pneumonia via multi-component, multi-target, and multi-pathway mechanisms. The putative active compounds are flavonoids, saccharides and glycosides, terpenoids, and phenylpropanoids, which act on targets such as TNF, AKT1, and IL-6 and regulate the TNF and IL-17 signaling pathways.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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