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Progress in research and application of organoid technology in drug research and development
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Hao-dong ZHONG1, 2, Qian-yi NIU1, 3, Tian LIN1, 2, Rui-qiu ZHANG1, 4, Man-man ZHAO1, 5, *, Xiao-bing ZHOU1, 5, *
Chinese Journal of New Drugs | 2026, 35(12) : 1251 - 1256
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Chinese Journal of New Drugs | 2026, 35(12): 1251-1256
Progress in research and application of organoid technology in drug research and development
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Hao-dong ZHONG1, 2, Qian-yi NIU1, 3, Tian LIN1, 2, Rui-qiu ZHANG1, 4, Man-man ZHAO1, 5, *, Xiao-bing ZHOU1, 5, *
Affiliations
  • 1Institute for Safety Evaluation, National Institutes for Food and Drug Control, Beijing Key Laboratory for Safety Evaluation of Drugs, Beijing 100176, China
  • 2China Pharmaceutical University, Nanjing 211198, China
  • 3Shenyang Pharmaceutical University, Shenyang 110016, China
  • 4Peking Union Medical College Hospital, Beijing 100006, China
  • 5State Key Laboratory of Drug Regulatory Science, Beijing 102629, China
Published: 2026-06-30 doi: 10.20251/j.cnki.1003-3734.2026.12.003
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Drug development is a complex and time-consuming process, and traditional drug research models have obvious limitations, and there is an urgent need to establish a new model system. Organoids are three-dimensional tissue analogues derived from stem cells that have attracted attention for their excellent physiological relevance. Organoid technology has shown great application potential in the fields of disease modeling, drug screening, toxicity testing, and personalized medicine, and can also be combined with organ-on-a-chip technologies to provide a new platform for the construction of complex physiological correlation models and the study of multi-organ interactions. This article reviews the development history of organoid technology and the progress in its research and application in drug development, discusses the challenges and development directions, to provide references for the key process of drug development and help promote the application and development of organoid technology in drug research and development.

organoids  /  personalized medicine  /  organ-on-a-chip
钟浩东, 牛茜怡, 林钿, 张瑞秋, 赵曼曼, 周晓冰. 类器官技术在药物研发中的研究和应用进展. 中国新药杂志, 2026 , 35 (12) : 1251 -1256 . DOI: 10.20251/j.cnki.1003-3734.2026.12.003
Hao-dong ZHONG, Qian-yi NIU, Tian LIN, Rui-qiu ZHANG, Man-man ZHAO, Xiao-bing ZHOU. Progress in research and application of organoid technology in drug research and development[J]. Chinese Journal of New Drugs, 2026 , 35 (12) : 1251 -1256 . DOI: 10.20251/j.cnki.1003-3734.2026.12.003
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Year 2026 volume 35 Issue 12
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.12.003
  • Online Date：2026-10-26
  • Published：2026-06-30
Article Data
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  • Accepted：2025-08-15
Funding
Affiliations
    1Institute for Safety Evaluation, National Institutes for Food and Drug Control, Beijing Key Laboratory for Safety Evaluation of Drugs, Beijing 100176, China
    2China Pharmaceutical University, Nanjing 211198, China
    3Shenyang Pharmaceutical University, Shenyang 110016, China
    4Peking Union Medical College Hospital, Beijing 100006, China
    5State Key Laboratory of Drug Regulatory Science, Beijing 102629, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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