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Advances in compression coating technology for sustained and controlled-release drug delivery systems
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Xiu-yi CHEN1, 2, 3, Wen ZHANG1, 2, 3, Chao CHEN1, 2, 3, Jing FENG1, 2, 3, Jin-hu WANG1, 2, Zhao-ming LI1, 2, Da-wei LI1, 2, 3, *
Chinese Journal of New Drugs | 2026, 35(8) : 853 - 860
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Chinese Journal of New Drugs | 2026, 35(8): 853-860
Advances in compression coating technology for sustained and controlled-release drug delivery systems
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Xiu-yi CHEN1, 2, 3, Wen ZHANG1, 2, 3, Chao CHEN1, 2, 3, Jing FENG1, 2, 3, Jin-hu WANG1, 2, Zhao-ming LI1, 2, Da-wei LI1, 2, 3, *
Affiliations
  • 1Shandong Academy of Pharmaceutical Science, Jinan 250101, China
  • 2Shandong Engineering Research Center for the New Controlled-release Preparation and Drug Targeted Delivery System, Jinan 250101, China
  • 3NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Jinan 250101, China
Published: 2026-04-30 doi: 10.20251/j.cnki.1003-3734.2026.08.009
Outline
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In the past two decades, the technology of compression-coated tablets has developed and progressed rapidly. Particularly, for the stepwise compression-coating technology, both the machine production capacity and the tablets quality have been greatly improved. And because the application of new excipients and new pharmaceutical technology, the prescription design ideas have been much optimized. Zero-order release tablets, pulsatile drug delivery tablets, floating drug delivery tablets, and colonic drug delivery tablets can be produced by compression coating technology, which can make blood drug concentrations more stable, improve the bioavailability of drugs or reduce adverse drug reactions, so the treatment of some diseases can be improved by these drug delivery tablets.

compression coating  /  sustained and controlled-release  /  zero-order release  /  pulsatile drug delivery  /  floating drug delivery  /  colonic drug delivery
陈修毅, 张雯, 陈超, 封静, 王金虎, 李兆明, 李大伟. 压制包衣技术在缓控释制剂中的应用与研究进展. 中国新药杂志, 2026 , 35 (8) : 853 -860 . DOI: 10.20251/j.cnki.1003-3734.2026.08.009
Xiu-yi CHEN, Wen ZHANG, Chao CHEN, Jing FENG, Jin-hu WANG, Zhao-ming LI, Da-wei LI. Advances in compression coating technology for sustained and controlled-release drug delivery systems[J]. Chinese Journal of New Drugs, 2026 , 35 (8) : 853 -860 . DOI: 10.20251/j.cnki.1003-3734.2026.08.009
Year 2026 volume 35 Issue 8
39
9
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.08.009
  • Online Date:2026-10-26
  • Published:2026-04-30
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History
  • Accepted:2025-06-30
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Affiliations
    1Shandong Academy of Pharmaceutical Science, Jinan 250101, China
    2Shandong Engineering Research Center for the New Controlled-release Preparation and Drug Targeted Delivery System, Jinan 250101, China
    3NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Jinan 250101, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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