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Successful correction of perioperative hypoalbuminemia with recombinant human albumin injection (Oryza Sativa) in a patient with allergy to human serum albumin: a case report
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Diligeer·TAYIER1, 2, Xian QIN1, 2, Ru-fang LIAO3, Zhi-yong YANG1, 2, *
Chinese Journal of New Drugs | 2026, 35(7) : 780 - 784
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Chinese Journal of New Drugs | 2026, 35(7): 780-784
Successful correction of perioperative hypoalbuminemia with recombinant human albumin injection (Oryza Sativa) in a patient with allergy to human serum albumin: a case report
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Diligeer·TAYIER1, 2, Xian QIN1, 2, Ru-fang LIAO3, Zhi-yong YANG1, 2, *
Affiliations
  • 1Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China
  • 2Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Wuhan 430000, China
  • 3Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430000, China
Published: 2026-04-15 doi: 10.20251/j.cnki.1003-3734.2026.07.015
Outline
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This article reports the case of a 70-year-old female patient scheduled for surgical intervention due to a space-occupying lesion at the distal common bile duct. The patient presented with severe allergic reactions to plasma-derived human serum albumin (pHSA), precluding its use for correcting hypoalbuminemia. Following informed consent, recombinant human albumin injection (Oryza Sativa) (OsrHSA) was administered as an alternative. The patient received a total of 70 g OsrHSA preoperatively in divided infusions, and her serum albumin level increased from 29.1 g·L-1 to 37.3 g·L-1 without adverse events. She subsequently underwent laparoscopic pancreaticoduodenectomy without complications. OsrHSA was also administered multiple times postoperatively, and no allergic reactions were observed. This case represented the successful application of OsrHSA as a safe alternative to pHSA in perioperative management for complex surgery. To the authors' knowledge, no similar reports have been published to date. This provides a new therapeutic avenue for patients with contraindications to human serum albumin, suggesting that plant-derived recombinant human albumin represents a safe and effective alternative.

rice-derived recombinant human albumin  /  human serum albumin  /  anaphylaxis  /  perioperative application  /  hypoalbuminemia
迪丽尼格尔·塔依尔, 秦弦, 廖如芳, 杨智勇. 重组人白蛋白注射液(水稻)成功纠正人血白蛋白过敏患者围手术期低蛋白血症的1例报告. 中国新药杂志, 2026 , 35 (7) : 780 -784 . DOI: 10.20251/j.cnki.1003-3734.2026.07.015
Diligeer·TAYIER, Xian QIN, Ru-fang LIAO, Zhi-yong YANG. Successful correction of perioperative hypoalbuminemia with recombinant human albumin injection (Oryza Sativa) in a patient with allergy to human serum albumin: a case report[J]. Chinese Journal of New Drugs, 2026 , 35 (7) : 780 -784 . DOI: 10.20251/j.cnki.1003-3734.2026.07.015
Year 2026 volume 35 Issue 7
29
5
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.07.015
  • Online Date:2026-10-26
  • Published:2026-04-15
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  • Accepted:2026-01-23
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Affiliations
    1Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China
    2Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Wuhan 430000, China
    3Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430000, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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