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Advances in surface-functionalized brain-targeted nano-drug delivery systems
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Yu ZHANG1, Sheng-nan LU2, Jun-li ZHANG1, Yao-yao ZHANG3, Ling CHENG3, Jing LI3, Ying LI2, Feng SU1, 2, 3, *, Guang-wei HE1, 2, 3, *
Chinese Journal of New Drugs | 2026, 35(8) : 785 - 794
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Chinese Journal of New Drugs | 2026, 35(8): 785-794
Advances in surface-functionalized brain-targeted nano-drug delivery systems
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Yu ZHANG1, Sheng-nan LU2, Jun-li ZHANG1, Yao-yao ZHANG3, Ling CHENG3, Jing LI3, Ying LI2, Feng SU1, 2, 3, *, Guang-wei HE1, 2, 3, *
Affiliations
  • 1School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
  • 2Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China
  • 3School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Published: 2026-04-30 doi: 10.20251/j.cnki.1003-3734.2026.08.001
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Central nervous system (CNS) diseases have become a major global public health challenge. With the extension of human lifespan and the intensification of population aging, the incidence of these diseases has shown a significant upward trend, yet their clinical treatment still faces critical technological bottlenecks. The presence of the blood-brain barrier (BBB) hinders the delivery of over 98% of small-molecule drugs and nearly all macromolecular drugs into the brain, rendering conventional drug administration methods unable to achieve effective therapeutic concentrations. In recent years, brain-targeted nano-drug delivery systems based on nanotechnology have demonstrated breakthrough potential: nanocarriers can improve the efficiency of drug crossing the BBB through size effects; surface functional modifications enable precise drug delivery to the brain. This article describes the composition and function of the BBB, the types of nanocarriers, and brain-targeting strategies via functional group modifications, aiming to provide theoretical foundations and technical references for developing safe and efficient brain-targeted nano-drug delivery systems.

nano-drug delivery system  /  brain-targeting  /  functional group ligand  /  blood-brain barrier  /  nanocarriers  /  central nervous system
张宇, 鲁胜男, 张俊丽, 张瑶瑶, 程玲, 李静, 李颖, 苏峰, 何广卫. 功能基修饰的脑靶向纳米递药系统研究进展. 中国新药杂志, 2026 , 35 (8) : 785 -794 . DOI: 10.20251/j.cnki.1003-3734.2026.08.001
Yu ZHANG, Sheng-nan LU, Jun-li ZHANG, Yao-yao ZHANG, Ling CHENG, Jing LI, Ying LI, Feng SU, Guang-wei HE. Advances in surface-functionalized brain-targeted nano-drug delivery systems[J]. Chinese Journal of New Drugs, 2026 , 35 (8) : 785 -794 . DOI: 10.20251/j.cnki.1003-3734.2026.08.001
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Year 2026 volume 35 Issue 8
44
7
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Article Info
doi: 10.20251/j.cnki.1003-3734.2026.08.001
  • Online Date：2026-10-26
  • Published：2026-04-30
Article Data
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History
  • Accepted：2025-06-09
Affiliations
    1School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
    2Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China
    3School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
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https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.08.001
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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