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A systematic review of the efficacy and safety of ferrous succinate tablets in the treatment of iron deficiency anemia during pregnancy
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Zhuo CHEN1, Li GAO2, Hui WANG3, Lu LIU2, Mei-xing YAN2, *
Chinese Journal of New Drugs | 2025, 34(17) : 1882 - 1890
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Chinese Journal of New Drugs | 2025, 34(17): 1882-1890
A systematic review of the efficacy and safety of ferrous succinate tablets in the treatment of iron deficiency anemia during pregnancy
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Zhuo CHEN1, Li GAO2, Hui WANG3, Lu LIU2, Mei-xing YAN2, *
Affiliations
  • 1Ocean University of China, Qingdao 266003, China
  • 2Qingdao Women and Children's Hospital, Qingdao 266034, China
  • 3Qingdao University, Qingdao 266071, China
Published: 2025-09-15 doi: 10.20251/j.cnki.1003-3734.2025.17.014
Outline
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Objective:

To systematically evaluate the efficacy and safety of ferrous succinate tablets in the treatment of iron deficiency anemia during pregnancy.

Methods:

Retrieved from PubMed, Embase, Cochrane Library, CNKI, Wanfang, randomized controlled trials (RCTs) about ferrous succinate versus polysaccharide iron complex capsules and ferrous sulfate tablets in the treatment of anemia during pregnancy and different dosage forms of ferrous succinate tablets for the treatment of iron-deficiency anemia in pregnancy were collected from January 2016 to April 2024. Meta-analysis was performed using RevMan 5.3 and Stata 17.0 software.

Results:

A total of 47 RCTs were retrieved with 6 655 patients. Results of meta-analysis showed that ferrous succinate tablets were significantly better than ferrous sulfate tablets in terms of overall efficacy [OR=4.65, 95%CI (3.68,5.88), P<0.000 01] and incidence of adverse reactions (P<0.05). There was no statistical significance in total response rate [OR=1.47，95％CI (0.45，4.79)，P=0.52] and specific adverse effect rates (P>0.05) between ferrous succinate tablets and polysaccharide iron complex capsules. The overall effectiveness and total incidence of adverse drug reactions in ferrous succinate sustained-release tablets were significantly better than that of ferrous succinate film-coated tablets.

Conclusion:

The efficacy and safety of ferrous succinate tablets in treating iron deficiency anemia in pregnancy are both good.

ferrous succinate  /  anemia in pregnancy  /  efficacy  /  safety  /  meta-analysis
Zhuo CHEN, Li GAO, Hui WANG, Lu LIU, Mei-xing YAN. A systematic review of the efficacy and safety of ferrous succinate tablets in the treatment of iron deficiency anemia during pregnancy[J]. Chinese Journal of New Drugs, 2025 , 34 (17) : 1882 -1890 . DOI: 10.20251/j.cnki.1003-3734.2025.17.014
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Year 2025 volume 34 Issue 17
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Article Info
doi: 10.20251/j.cnki.1003-3734.2025.17.014
  • Online Date：2026-03-06
  • Published：2025-09-15
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History
  • Accepted：2024-10-17
Funding
Affiliations
    1Ocean University of China, Qingdao 266003, China
    2Qingdao Women and Children's Hospital, Qingdao 266034, China
    3Qingdao University, Qingdao 266071, China
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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