To evaluate the effect of Multi-Trace Element Injection (I) on postoperative inflammatory indexes in children with appendicitis.

A total of 68 patients who underwent laparoscopic appendectomy for perforated appendicitis in the Department of General Surgery of Fudan University affiliated pediatric hospital from March 2022 to December 2022 were randomly divided into an experimental group and a control group. The experimental group was given Multi-Trace Element Injection (I) at a dosage of 1 mL·kg^-1·d^-1 based on routine anti-infection treatment, with a 7-day treatment course. The control group only received routine anti-infection treatment. The inflammatory indexes, abdominal ultrasound and adverse reactions of children in the two groups were compared on the 4th and 7th day post-surgery.

The comparison of CRP value changes between the experimental and control groups 4 days after surgery showed that the experimental group had a baseline change of -85.2（-123，-48.2）, while the control group had a baseline change of -64.0 （-86.2，-26.5）, and the difference was statistically significant (P<0.05). Compared with preoperative levels, the change in PCT 4 days after surgery was -2.30 (-2.50, -2.0) in the experimental group and -0.880 (-2.50, -0.968) in the control group, with a statistically significant difference (P<0.05). The change in WBC count compared to preoperative levels was -7.52 (-10.7, -4.04) in the experimental group and -4.34 (-7.90, -1.19) in the control group, with no statistically significant difference (P>0.05). The comparison of CRP changes between the experimental and control groups 7 days after surgery showed that the experimental group had a baseline change of -125 (-135, -61.2), and the control group had a baseline change of -104 (-149, -76.2), with no statistically significant difference (P>0.05). The change in PCT compared to preoperative levels was -2.79 (-5.41, -1.05) in the experimental group and -1.71 (-4.08, -0.435) in the control group, with no statistically significant difference (P>0.05). The change in WBC count compared to preoperative levels was (-6.63±5.55) in the experimental group and (-6.41±6.64) in the control group, with no statistically significant difference (P>0.05). Covariate analysis showed that after controlling for the status of Multi-Trace Element Injection (I), the experimental group was significantly better than the control group in reducing CRP, PCT and WBC count (P<0.05). This indicates that Multi-Trace Element Injection (I) has a significant effect on reducing inflammation. The effect of the experimental group remained significant under the control of these covariates. There was no statistically significant difference in the incidence of adverse reactions, abdominal ultrasound findings and hospitalization days between the two groups of children (P>0.05).

The application of Multi-Trace Element Injection (I) after laparoscopic appendectomy is safe and effective, and can further reduce postoperative inflammation in children and promote infection improvement.