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Efficacy and safety comparison of ceftazidime avibactam versus colistin/polymyxin B in the treatment of carbapenem-resistant Gram-negative bacilli infection: a systematic review
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Ye CAO1, Ying-qiu YING1, 2, Ming LU3, Jia-jia ZHENG4, Li YANG1, 2, Suo-di ZHAI1, 2
Chinese Journal of New Drugs | 2023, 32(7) : 670 - 675
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Chinese Journal of New Drugs | 2023, 32(7): 670-675
Efficacy and safety comparison of ceftazidime avibactam versus colistin/polymyxin B in the treatment of carbapenem-resistant Gram-negative bacilli infection: a systematic review
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Ye CAO1, Ying-qiu YING1, 2, Ming LU3, Jia-jia ZHENG4, Li YANG1, 2, Suo-di ZHAI1, 2
Affiliations
  • 1Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China
  • 2Institute for Drug Evaluation, Peking University Health Science Center, Beijing 100191, China
  • 3Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China
  • 4Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
Published: 2023-04-15
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Objective: To systematic review the efficacy and safety of ceftazidime avibactam (CAZ/AVI) and colistin/polymyxin B in the treatment of carbapenem-resistant Gram-negative bacilli infection.Methods: Cochrane Library, PubMed, Embase, CNKI and Wanfang data were searched to collect randomized controlled or cohort studies of ceftazidime avibactam and colistin/polymyxin B in the treatment of carbapenem-resistant Gram-negative bacilli infection. The retrieval time was from the establishment of each database to May 2022. After literature screening and data extraction, NOS was used to evaluate the quality of literature.Results: Totally 7 studies were finally enrolled, with a total of 801 patients. The results of Meta-analysis showed that the mortality rate and incidence of kidney injury in CAZ/AVI group were lower than those in colistin/polymyxin B group (P<0.005), while the clinical cure rate and bacterial clearance rate were higher than those in colistin/polymyxin B group (P<0.005).Conclusion: The clinical efficacy and safety of CAZ/AVI in the treatment of carbapenem-resistant Gram-negative bacilli infection showed better efficacy and lower incidence of kidney injury compared with the control group.

ceftazidime avibactam  /  colistin  /  polymyxin B  /  carbapenem resistance  /  efficacy  /  safety
Ye CAO, Ying-qiu YING, Ming LU, Jia-jia ZHENG, Li YANG, Suo-di ZHAI. Efficacy and safety comparison of ceftazidime avibactam versus colistin/polymyxin B in the treatment of carbapenem-resistant Gram-negative bacilli infection: a systematic review[J]. Chinese Journal of New Drugs, 2023 , 32 (7) : 670 -675 .
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Year 2023 volume 32 Issue 7
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  • Online Date：2026-03-06
  • Published：2023-04-15
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  • Accepted：2022-10-17
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Affiliations
    1Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China
    2Institute for Drug Evaluation, Peking University Health Science Center, Beijing 100191, China
    3Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China
    4Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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