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Lonapegsomatropin-tcgd (tradename: SkytrofaTM) is the first long-acting new drug approved by FDA for the treatment of growth hormone deficiency in children. It can continuously release growth hormone and needs to be injected for only once a week. Lonapegsomatropin-tcpd improves patient compliance by reducing dosing frequency compared to traditional daily somatropin injection therapy. Clinical studies confirmed that weekly treatment of lonapegsomatropin-tcpd showed a higher annual growth velocity at week 52 compared with somatropin. In this article, the mechanism, pharmacokinetics, pharmacodynamics, clinical evaluation, safety, drug interaction and storage of lonapegsomatropin-tcpd are reviewed.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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