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Progress in the clinical study of antidepressant drugs with different mechanisms
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Hui-ying WANG1, Ai-nan ZHOU2, Jian-wei WU3, Peng XIE3, Jian-qi LI3
Chinese Journal of New Drugs | 2023, 32(7) : 676 - 686
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Chinese Journal of New Drugs | 2023, 32(7): 676-686
Progress in the clinical study of antidepressant drugs with different mechanisms
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Hui-ying WANG1, Ai-nan ZHOU2, Jian-wei WU3, Peng XIE3, Jian-qi LI3
Affiliations
  • 1School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
  • 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 3New Technology Center of Chemical Pharmacy, Shanghai Institute of Pharmaceutical Industry, China General Research Institute of Pharmaceutical Industry, Shanghai 201203, China
Published: 2023-04-15
Outline
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At present, the listed antidepressants have certain limitations, and the different mechanisms of which are closely related to their efficacy and safety. Therefore, the discovery of antidepressants with novel mechanisms is an important research direction in the field of antidepressants. This paper reviews some major antidepressants currently under clinical research stage, and analyzes their mechanisms of action, so as to provide reference for the development of antidepressants with new mechanisms of action.

antidepressants  /  limitations  /  mechanisms of action  /  clinical research
Hui-ying WANG, Ai-nan ZHOU, Jian-wei WU, Peng XIE, Jian-qi LI. Progress in the clinical study of antidepressant drugs with different mechanisms[J]. Chinese Journal of New Drugs, 2023 , 32 (7) : 676 -686 .
Year 2023 volume 32 Issue 7
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  • Online Date:2026-03-06
  • Published:2023-04-15
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  • Accepted:2022-10-20
Affiliations
    1School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
    2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    3New Technology Center of Chemical Pharmacy, Shanghai Institute of Pharmaceutical Industry, China General Research Institute of Pharmaceutical Industry, Shanghai 201203, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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