PDF
Full
Outline
Objective: To establish a quantitative proton nuclear magnetic resonance method for the determination of vemurafenib.Methods:The structure of vemurafenib was confirmed by MS and NMR. The spectra of proton nuclear magnetic resonance spectroscopy were obtained in dimethylsulfoxide-d6 by using Bruker ANANCE NEO 600, the parameters of which were set up as follows: 90° pulse sequences, the relaxation delay time was 15 s, the number for scanning was 32, the experiment temperature was controlled at 25 ℃, and hydroquinone were selected as internal standard. The quantitative study was conducted on vemurafenib.Results:The 1H and 13C NMR spectra of vemurafenib was assigned. The content of vemurafenib determined by qHNMR were 98.78%, which was basically consistent with the results of mass balance method (98.91%).Conclusion:The method is simple, rapid and accurate, and can be used for the determination of vemurafenib.
PDF
26
7
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
