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Structural modification and biological research progress of rhein
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Xin GAO1, Fang FANG1, 2, 3
Chinese Journal of New Drugs | 2023, 32(1) : 35 - 45
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Chinese Journal of New Drugs | 2023, 32(1): 35-45
Structural modification and biological research progress of rhein
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Xin GAO1, Fang FANG1, 2, 3
Affiliations
  • 1College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
  • 2Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China
  • 3Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China
Published: 2023-01-15
Outline
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Rhein is a kind of emodin-type hydroxy-anthraquinone, which mainly exists in traditional Chinese medicines like rhubarb. Rhein is well acknowledged for its pharmacological activities, such as anti-cancer, anti-inflammatory, anti-bacterial and anti-Alzheimer's disease; however, its clinical application is limited due to its poor water solubility and low bioavailability. In order to overcome these shortcomings, a large number of more bioactive Rhein derivatives were designed and synthesized by structural modification of Rhein. In this paper, the structural modification and pharmacological activity of rhein are reviewed, providing reference for future development of rhein derivatives.

rhein  /  derivatives  /  structural modification  /  biological activity
Xin GAO, Fang FANG. Structural modification and biological research progress of rhein[J]. Chinese Journal of New Drugs, 2023 , 32 (1) : 35 -45 .
Year 2023 volume 32 Issue 1
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  • Online Date:2026-03-06
  • Published:2023-01-15
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  • Accepted:2022-05-20
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Affiliations
    1College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
    2Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China
    3Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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