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Nanotechnology has greatly promoted the research and development of nanodrugs and nanoparticles, providing new therapeutic options for many diseases. However, due to their special physical and chemical properties and its easy accumulation in the liver, nanodrugs and nanoparticles can also bring potential hepatotoxicity risks to the body. This review summarizes the research progress of hepatotoxicity induced by nanodrugs or nanoparticles in recent years from the following three aspects: liver accumulation and cell-nanodrug interaction, toxic mechanisms and influencing factors of toxicity. Also, we discuss the limitations of the previous studies. This paper aims to provide new insights and references for the related researches on hepatotoxicity and preclinical safety evaluation of nanodrugs and nanoparticles.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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