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A systematic evaluation of meta analyses on the correlation between short-term endpoints and final endpoints in cancer
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Zheng-yang FEI, Hong-fei HU, Lei SUN, Ping-yu CHEN, Ying-cheng WANG, Ming-jun RUI, Hong-chao LI
Chinese Journal of New Drugs | 2023, 32(1) : 93 - 102
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Chinese Journal of New Drugs | 2023, 32(1): 93-102
A systematic evaluation of meta analyses on the correlation between short-term endpoints and final endpoints in cancer
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Zheng-yang FEI, Hong-fei HU, Lei SUN, Ping-yu CHEN, Ying-cheng WANG, Ming-jun RUI, Hong-chao LI
Affiliations
  • School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing 211198, China
Published: 2023-01-15
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Objective: To summarize the evaluation of meta analyses on the correlation between short-term endpoints (ORR, CR, etc.) and final endpoints (PFS, OS) in cancer, and to explore the correlation between different types of cancer. Methods: Based on Cooper et al. (2020), a systematic search in databases of Medline, Embase, the Cochrane library, Web of Science, and CINAHL were updated from March 2019 to January 2022. Meta analyses assessing the individual-level and trial-level correlation between short-term intermediate endpoints and final endpoints are summarized, and subgroup analyses are conducted in terms of the three most common cancer types. Results: The systematic review includes 77 studies across 20 types of cancer, in which non small cell lung cancer (NSCLC), colorectal cancer (CRC), and breast cancer are the three most common cancer types. The included studies mainly analyzed the correlation between ORR and OS (91%) or PFS (35%), and the correlation was week regardless of individual-level and trial-level. In subgroup analyses, over half studies in NSCLC indicated good or excellent trial-level correlation between ORR and PFS (R2>0.4). Also, most studies in NSCLC and CRC indicated that the trial-level correlation between ORR and PFS >0.3, >0.2) was stronger than that between ORR and OS (>0.1, >0.1). Conclusion: The short-term intermediate endpoints, such as ORR, may not be good surrogates for final endpoints. ORR may be a short-term intermediate indicator worth be noticed by regulators, which could be surrogate for PFS in trial-level in the field of NSCLC and CRC, especially in the field of NSCLC.

short-term endpoints  /  final endpoints  /  correlation  /  systematic review  /  cancer
Zheng-yang FEI, Hong-fei HU, Lei SUN, Ping-yu CHEN, Ying-cheng WANG, Ming-jun RUI, Hong-chao LI. A systematic evaluation of meta analyses on the correlation between short-term endpoints and final endpoints in cancer[J]. Chinese Journal of New Drugs, 2023 , 32 (1) : 93 -102 .
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  • Online Date：2026-03-06
  • Published：2023-01-15
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  • Accepted：2022-05-10
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    School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing 211198, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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