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Neuroprotective effect and mechanism of acteoside on mouse model of MPTP-induced Parkinson's disease
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Fang TIAN1, Xin-yi DONG2, Chong DU3, Ya-juan GAO4, 5, Xiao-ping PU6
Chinese Journal of New Drugs | 2023, 32(6) : 618 - 624
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Chinese Journal of New Drugs | 2023, 32(6): 618-624
Neuroprotective effect and mechanism of acteoside on mouse model of MPTP-induced Parkinson's disease
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Fang TIAN1, Xin-yi DONG2, Chong DU3, Ya-juan GAO4, 5, Xiao-ping PU6
Affiliations
  • 1Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, China
  • 2Department of Pharmacy, Tianjin Medical University Eye Hospital, Tianjin 300384, China
  • 3Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China
  • 4Department of Radiology, Peking University Third Hospital, Beijing 100191, China
  • 5NMPA Key Laboratory for Evaluation of Medical Imaging Equipment and Technique, Beijing 100191, China
  • 6Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Published: 2023-03-30
Outline
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Objective:

To explore the neuroprotective effect of acteoside (ACT) on mouse model of MPTP-induced Parkinson's disease (PD) and its mechanism.

Methods:

The PD mouse model was established by intraperitoneal injection of MPTP. The experimental mice were randomly divided into control group, model group and ACT group (100 mg·kg-1), which were administrated by gavage for 14 d. After administration, behavioral evaluation and biochemical detection were performed to evaluate the neuroprotective effect of ACT on PD mice. Two-dimensional electrophoresis, mass spectrometry and Western blot were used to further explore the anti-PD mechanism of ACT.

Results:

After prophylactic administration of ACT, the pole climbing time of MPTP-induced PD mice was significantly shortened, swimming test score was improved, suspension duration was prolonged, and hind limb tension test score and cylinder test score were decreased. ACT could effectively improve the activities of SOD, CAT, and GSH-Px in the substantia nigra and striatum of MPTP-induced PD mice and reduce the content of MDA. The results of two-dimensional electrophoresis and Western blot showed that the expression of biliverdin reductase B (BLVRB) increased in the substantia nigra and striatum of PD mice induced by MPTP, while the expression of BLVRB decreased significantly after the administration of ACT.

Conclusion:

ACT has neuroprotective effect on MPTP-induced PD mice, and its underlying mechanism may be related to the decrease of BLVRB expression and anti-oxidative stress of ACT.

acteoside  /  Parkinson's disease  /  neuroprotective effect  /  oxidative stress  /  biliverdin reductase B
Fang TIAN, Xin-yi DONG, Chong DU, Ya-juan GAO, Xiao-ping PU. Neuroprotective effect and mechanism of acteoside on mouse model of MPTP-induced Parkinson's disease[J]. Chinese Journal of New Drugs, 2023 , 32 (6) : 618 -624 .
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Year 2023 volume 32 Issue 6
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Article Info
  • Online Date：2026-03-06
  • Published：2023-03-30
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History
  • Accepted：2023-01-18
Funding
Affiliations
    1Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, China
    2Department of Pharmacy, Tianjin Medical University Eye Hospital, Tianjin 300384, China
    3Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China
    4Department of Radiology, Peking University Third Hospital, Beijing 100191, China
    5NMPA Key Laboratory for Evaluation of Medical Imaging Equipment and Technique, Beijing 100191, China
    6Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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