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To investigate the antibacterial effect of acetylkitasamycin dry suspension on Mycoplasma pneumoniae (MP) in vitro.
51 clinical isolates and 2 standard strains of MP from patients with respiratory tract infection stored in our laboratory from 2016 to 2019 were randomly selected for the research. Taking azithromycin and erythromycin as control drugs, the minimum inhibitory concentration (MIC) of acetylkitasamycin dry suspension against MP was determined using broth microdilution method.
Of all the 51 clinical isolates, there were 43 drug-resistant strains that contained the point mutations A2063G in V region of 23S rRNA domain, and there were 8 susceptible strains which had no mutations related to drug resistance. The MIC values of the acetyljithamycin dry suspension were 0.125 mg·L-1 for the standard MP strains FH and M129; for the clinically resistant MP strains, the MIC was 8~32 mg·L-1, the MIC50 was 16 mg·L-1, and the MIC90 was 32 mg·L-1; for clinically sensitive MP strains, the MIC was 0.063~0.125 mg·L-1, and both MIC50 and MIC90 were 0.125 mg·L-1. Erythromycin had a MIC range of 256~1 024 mg·L-1 for clinically resistant MP strains, the MIC50 was 512 mg·L-1, and the MIC90 was 1 024 mg·L-1; azithromycin had a MIC range of 64~512 mg·L-1 for clinically resistant MP strains, the MIC50 was 256 mg·L-1, and the MIC90 was 512 mg·L-1. The MIC values of erythromycin and azithromycin for clinically sensitive MP strains were <0.5 mg·L-1.
MP showed different degrees of resistance to macrolide antibiotics. Acetylkitasamycin dry suspension had good bacteriostatic activity against sensitive MP strains in vitro, and the MIC value against resistant MP strains was low, and the clinical effect on MP infection need to be further studied.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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