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To determine the key influencing factors on formation of prasugrel hydrogen sulfate polymorph during the reactive crystallization of prasugrel free alkali and sulfuric acid, clarify the rule of the influences of solvent, temperature, and supersaturation, and reveal the mechanism of prasugrel hydrogen sulfate polymorph formation.
Based on combined application of X-ray diffraction spectroscopy (PXRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), this study focused on the crystallization thermodynamics and reactive crystallization process of prasugrel hydrogen sulfate. The stability relationship between the polymorphs of prasugrel hydrogen sulfate and the influencing rule of polymorph formation during reaction crystallization were investigated.
It was shown that solvent and supersaturation were the key factors affecting the formation of prasugrel hydrogen sulfate polymorphs.
Prasugrel hydrogen sulfate form Ⅰ and form Ⅱ are monotropically related systems, and form Ⅱ is a stable form. Solvent plays a leading role in the formation of prasugrel hydrogen sulfate polymorphs, and the formation of polymorphs in butanol obeys to the Ostwald's rule.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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