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To explore the predictors of the clinical response to tofacitinib in rheumatoid arthritis (RA).
The clinical data of a cohort of 256 RA patients regularly followed up at the Department of Rheumatology and Immunology, Peking University People's Hospital were analyzed, among whom 121 patients with DAS28-ESR≥3.2 were treated with tofacitinib. Data were collected from patients starting to receive tofacitinib and at 6-month follow-up to evaluate the remission rate and analyze the predictors for achieving Boolean 3v remission.
Out of 121 patients treated with tofacitinib, 104 patients (86.0%) were treated with tofacitinib for more than 6 months and 17 patients changed medication within 6 months, including 10 patients (8.3%) due to poor efficacy and 7 patients (5.8%) for adverse effects. After 6 months of follow-up, the remission rates according to Boolean 3v, DAS28-ESR and CliDR were 72.8%, 57.0% and 44.7%, respectively. The EULAR response rate was 88.6%. Multivariable logistic regression analysis showed that gender, number of conventional synthetic DMARDs resistance and glucocorticoid combination were independent predictors for Boolean 3v remission after 6 months of tofacitinib treatment.
Female patients without glucocorticoids and a small number of conventional synthetic DMARDs resistance tend to get better response to tofacitinib.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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