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To retrospectively analyze the cardiac adverse events and death cases of EGFR inhibitors through data mining of FDA adverse reaction reporting system (FAERS), so as to better understand the safety of EGFR inhibitors.
The data in a total of 36 quarters in FAERS database from 2013 to 2021 were mined and analyzed by reporting odds ratio (ROR).
A total of 30 728 493 adverse events were reported in FAERS database from 2013 to 2021, including 735 693 cardiac adverse events. The effective signals were cetuximab [ROR=1.16, 95%CI (1.07,1.26)], rituximab [ROR=2.94, 95%CI (1.61,5.36)], dactinib [ROR=3.73, 95%CI (2.10,6.62)], and ositinib [ROR=1.55, 95%CI (1.44,1.66)]. McAbs were more likely to cause tachycardia. All heart-related effective signals of TKIs contained pericardial effusion. The significant death signals were panizumab [ROR=1.71, 95%CI (1.54,1.89)], gefitinib [ROR=2.93, 95%CI (2.64,3.25)], erlotinib [ROR=6.72, 95%CI (6.54,6.91)], afatinib [ROR=1.30, 95%CI(1.17,1.45)], dactinib [ROR=14.24, 95%CI (11.27,17.99)], and ositinib [ROR=15.03, 95%CI (14.53,15.54)].
EGFR receptor inhibitors can cause adverse cardiac events with serious outcomes and increase the risk of death, which are worthy of clinical attention. Due to the limitations of database and detection methods, long-term data are still needed to verify these results to further understand the safety of EGFR inhibitors.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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